第一章　血管內皮功能總論 ···············································································1
一、血管內皮細胞的作用 ················································································1
二、血管內皮功能異常的機制 ··········································································3
三、血管內皮功能異常反映出的問題 ·································································9
四、血管內皮功能檢測的臨床應用 ·································································· 10
五、血管內皮功能障礙到動脈硬化 ·································································· 12
六、血管內皮功能異常導致冠狀動脈痙攣性心絞痛 ············································· 15
七、當前血管內皮功能為何受到關注？ ···························································· 16
八、血管內皮功能在循環(huán)系統(tǒng)預防醫(yī)學中的定位 ················································ 16
第二章　血管內皮功能檢測技術 ······································································· 21
一、體積描記法 ·························································································· 21
二、 基于血管超聲檢測的血流介導的血管擴張 ··················································· 21
三、 可替代FMD 的踝肱指數(shù)輕度異常值 ·························································· 22
四、 指端脈搏波反應性充血外周動脈張力 ························································· 23
五、FMD 與RHI 的區(qū)別 ··············································································· 24
六、前臂充血與上臂充血 ·············································································· 25
七、反映血管內皮功能的生物標志物 ······························································· 25
八、冠狀動脈的內皮功能 ·············································································· 28
第三章　血管內皮功能檢測所提供的信息 ··························································· 31
一、血管內皮功能檢測的篩查作用 ·································································· 31
二、血管內皮功能檢測是動脈硬化進程的評價指標 ············································· 31
三、預測冠狀動脈疾病的預后 ········································································ 32
四、冠狀動脈痙攣性心絞痛的診斷 ·································································· 33
五、心臟微血管障礙的診斷與療效評估 ···························································· 33
六、深靜脈血栓癥的篩查 ·············································································· 34
七、預測外周動脈疾病的預后 ········································································ 35
目　錄
2　血管內皮功能診斷——循環(huán)系統(tǒng)疾病管理的評價指標與實踐
第四章　血管內皮功能障礙相關疾病的發(fā)病機制 ·················································· 39
一、一氧化氮 ····························································································· 39
二、炎癥 ··································································································· 40
三、氧化應激 ····························································································· 40
四、自主神經 ····························································································· 42
第五章　血管內皮功能提供的臨床依據(jù) ······························································ 45
一、血管內皮功能相關的基礎研究 ·································································· 45
二、血管內皮功能的臨床研究 ········································································ 46
第六章　心血管病及血管內皮功能的相關因素 ····················································· 51
一、冠狀動脈疾病家族史 ·············································································· 51
二、少鹽 ··································································································· 51
三、吸煙 ··································································································· 52
四、高血壓 ································································································ 52
五、糖尿病、糖代謝異常 ·············································································· 53
六、脂質異常 ····························································································· 54
七、高尿酸血癥 ·························································································· 55
八、慢性腎病 ····························································································· 55
九、肥胖、代謝綜合征 ················································································· 56
十、睡眠呼吸暫停綜合征 ·············································································· 57
十一、運動、體育鍛煉 ················································································· 57
十二、高齡與性別 ······················································································· 59
十三、心律不齊 ·························································································· 59
十四、動脈硬化性疾病 ················································································· 59
十五、靜脈血栓栓塞癥 ················································································· 61
十六、心力衰竭 ·························································································· 63
十七、肺動脈高壓 ······················································································· 64
十八、血流動力學狀態(tài) ················································································· 64
十九、抑郁癥 ····························································································· 65
二十、維生素、礦物質 ················································································· 65
二十一、不飽和脂肪酸 ················································································· 66
第七章　血管內皮功能在臨床中的應用實踐 ························································ 73
一、肥胖患者的減重指導 ·············································································· 74
　目　錄　3
二、預防動脈硬化的心血管疾病管理 ······························································· 74
三、心臟康復的風險分層與效果評價 ······························································· 77
四、評價預防缺血性心臟病復發(fā)的干預治療效果 ················································ 78
五、心力衰竭的療效評價 ·············································································· 79
六、預測心血管不良事件的發(fā)生 ····································································· 80
后記············································································································ 83
縮略詞一覽表································································································ 84
索引············································································································ 88
作者簡介······································································································ 90